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Also available at Zenodo
Department of biochemistry and microbiology focus on basic research in areas of retroviral molecular biology, proteomics, plant physiology and molecular genetics, enzymology, environmental microbiology, food microbiology and bioanalytical methods. These activities create a platform for applied research aimed at developing modern therapeutic approaches, bioremediation of inorganic and organic pollutants, monitoring food safety and quality (the department also operates accredited Testing Laboratory of the Institute of Biochemistry and Microbiology) or plant-pathogen interaction. Research in our department is in many cases interdisciplinary and, in addition to close professional cooperation between the individual laboratories of the department, it would be unthinkable without cooperation with a number of national and foreign groups within the framework of joint research programs and projects. Currently, we are working on projects supported by the Czech Science Foundation, Technology Agency of the Czech Republic, Ministry of Agriculture of the Czech Republic, Ministry of Industry and Trade of the Czech Republic and the Ministry of Education and Sports.
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Advanced Biochemistry, Applied Enzymology, Environmental Microbiology, Food microbiology and Genetic engineering are delivered in English for foreign students.
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[perex] => We are dedicated to investigating the immunotoxicity and toxicity of new materials and pollutants and their impact on cells, with a particular focus on macrophages and basophils. We are deeply committed to advancing our understanding of the interactions between these materials and the human immune system, specifically in relation to the generation of reactive oxygen species (ROS) and the development of allergies. Understanding how these materials affect our cells is critical for assessing their safety in industrial and medical applications.
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[obsah] => Macrophages are one of the key players in the immune response, and we investigate how exposure to novel materials can influence their function. We study the phagocytic activity, cytokine production, and ROS generation in human macrophages when exposed to different materials to determine their impact on immune defense mechanisms.
Other immune cells basophils are essential in allergic reactions, and we explore how exposure to novel materials can trigger allergic responses. Our research focuses on the degranulation of basophils and the release of pro-inflammatory mediators, which play a pivotal role in allergy development, which nowadays become more common than ever before.
Reactive oxygen species are involved in various cellular processes, including immune responses. We investigate how new materials can induce ROS production in immune cells, and evaluate the potential consequences of elevated ROS levels, such as oxidative stress and inflammation.
We are dedicated to advancing the field of immunotoxicology and its applications in assessing the safety of emerging materials. By investigating the impact of novel materials on human immune cells, as well as the impact of elevated ROS and allergy development, we aim to provide critical insights that promote the responsible and safe use of these materials in various industries while safeguarding human health.
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