We are dedicated to investigating the immunotoxicity and toxicity of new materials and pollutants and their impact on cells, with a particular focus on macrophages and basophils. We are deeply committed to advancing our understanding of the interactions between these materials and the human immune system, specifically in relation to the generation of reactive oxygen species (ROS) and the development of allergies. Understanding how these materials affect our cells is critical for assessing their safety in industrial and medical applications.
Macrophages are one of the key players in the immune response, and we investigate how exposure to novel materials can influence their function. We study the phagocytic activity, cytokine production, and ROS generation in human macrophages when exposed to different materials to determine their impact on immune defense mechanisms.
Other immune cells basophils are essential in allergic reactions, and we explore how exposure to novel materials can trigger allergic responses. Our research focuses on the degranulation of basophils and the release of pro-inflammatory mediators, which play a pivotal role in allergy development, which nowadays become more common than ever before.
Reactive oxygen species are involved in various cellular processes, including immune responses. We investigate how new materials can induce ROS production in immune cells, and evaluate the potential consequences of elevated ROS levels, such as oxidative stress and inflammation.
We are dedicated to advancing the field of immunotoxicology and its applications in assessing the safety of emerging materials. By investigating the impact of novel materials on human immune cells, as well as the impact of elevated ROS and allergy development, we aim to provide critical insights that promote the responsible and safe use of these materials in various industries while safeguarding human health.
